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Experimental evidence from human tumor cell lines derived from either colon, breast, melanoma, osteosarcoma and prostate cancers showed increased exosomal release as the pH was changed from 7.4 to 6.5, supporting the notion that acidic TME is associated with increased exosome production and represents a key phenotype of all human cancers [155]

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We used our model to study the effect of increased activity of the P450 enzymes on the level of NAPQI covalent binding and the predicted associated level of hepatic cell necrosis