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pylori infection Intestinal permeability Inflammatory bowel disorders The gut and skin communicate through inflammatory and immune pathways often referred to as the “gut-skin axis.” When gut integrity becomes disrupted: Inflammatory cytokines increase Histamine signaling rises Immune activation escalates Skin barrier function worsens This inflammatory cascade may directly contribute to rosacea flares

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2D Molecular Structure Interactive 3D Structure Structural Representation: The 2D image is a database-derived molecular structure reference