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A recent study showed that glucose metabolism was dysregulated and that pyruvate supplementation could prevent neurodegeneration in an animal model of glaucoma 31 , suggesting that ATP production from glycolysis is disrupted, and that other energy fuel pathways, such as β-oxidation, may be augmented to compensate for the reduction in energy metabolism

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However, it is critical to recognize that clinical symptoms of deficiency can manifest without anemia or low serum vitamin B12 levels