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Briefly, as described (42), passage obstruction scored 0–3 (according to the loop diameters ratio close to anastomosis, loop diameters orally/loop diameters aborally = 1 passage is normal (score 0), between 1 and 1.33 is the sign of mild obstruction (score 1), between 1.33 and 1.66 is moderate obstruction (score 2), and more than 1.66 is severe obstruction (score 3))

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It was first described in the early 1990s, and since then has been extensively studied in preclinical models for its effects on tissue repair, angiogenesis, and gastrointestinal function