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In a model of Aβ-induced neuronal injury, lycopene did not activate NF-κB, p65, or TLR4 expression (Tripathi et al., 2018), but restored mitochondrial morphological membrane potential and ATP levels (Qu et al., 2016) and inhibited Bax and mitochondria

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Elevated intracellular iron can saturate NM’s binding sites, causing iron release from low-affinity sites and enhancing iron-driven oxidative stress (128)

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