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Erythrocyte glutathione transferase: a general probe for chemical contaminations in mammals | Cell Death Discovery

Research has indicated that biomarkers linked to oxidative stress, such as urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), nitrite (NO 2 – ), nitrate (NO 3 – ), and biopyrrin, are significantly increased in AD patients (22–24)

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By extracting aortic tissue from the mice and performing WB analysis, we found that the expression levels of P53 and FOXO4 were both elevated (Supplementary Figure S1A)