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Notably, PPARγ alone is not sufficient to restore redox homeostasis and promote the M2 phenotype, as demonstrated by the exacerbation of neuroinflammatory cytokine production in NRF2-deficient mice challenged with LPS (Innamorato et al., 2008)

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corroborated these findings in more detail in the Framingham Heart Study which examined 3,451 participants over 19 years who were stratified into four groups based on GGT level